Fluconazole tablet (हिन्दी मे) uses, dosage, side effects. An overview
What Is Fluconazole (Diflucan)?
Fluconazole, sold under the brand name Diflucan, is a medication used to treat fungal infections like thrush in the mouth and throat and yeast infections in women.
Fluconazole belongs to group of drugs known as antifungals, which work by preventing fungus from making its own form of plant-based cholesterol that the fungus needs to survive.
Fluconazole was approved by the Food and Drug Administration (FDA) under the brand name Diflucan in 1990, and is manufactured by Pfizer.
If you are allergic to fluconazole or any of its inactive ingredients, you should not take fluconazole.
If you are taking medications that can change the electrical activity in the heart you should not take this drug.
Also, if you have severe kidney problems (kidneys with a creatinine clearance, CrCl, or urine output 50 ml/ minute or less), your body may not be able to eliminate fluconazole as quickly as it should.
Your doctor may need to find a special dose that works best for you.
Be sure to let your doctor know that you have kidney problems before taking this medication. People who are on dialysis should receive the full dose of fluconazole after they have finished their dialysis procedure.
Talk to your doctor before taking fluconazole if you:
Additionally, if you are allergic to azoles (the building block of a certain class of antifungal drugs that includes fluconazole), you should not take fluconazole.
It should also be noted that people with certain sensitivities must be careful with various dosage forms of fluconazole.
For example, people who may have inherited certain genetic conditions, including intolerances to certain sugars, such as glucose-galactose, lapp lactase, or sucrose, should avoid Diflucan capsules because they contain lactose.
People with glycerol sensitivities should avoid fluconazole syrups because the glycerol may cause unpleasant symptoms like diarrhea, stomach discomfort, or headaches.
Pregnancy and Fluconazole
In general, it's not recommended that pregnant women take this medication.
Fluconazole can harm the fetus and should only be taken in situations when there are no other safer options available.
Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Fluconazole has been found to pass into breast milk, so alert your physician if you are breastfeeding or plan to breastfeed.
Fluconazole Coupons and Prices
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Fluconazole Side Effects
Common Side Effects of Fluconazole
Headache is the most common side effect of taking fluconazole. Other side effects include: nausea, diarrhea, vomiting, rash, and stomach pain.
Serious Side Effects of Fluconazole
- Changes in heart rhythm or electrical activity in the heart
- Liver failure and inflammation, including an increase in liver enzyme levels and yellowing of the skin, nails, and whites of the eyes (jaundice)
- Swelling of the lips, mouth, and tongue (angioedema)
- A drop in white blood cell count or platelet count
- Difficulty breathing
- High triglycerides, low potassium levels in the blood
- Severe and potentially life-threatening skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis (TENs)
Rare Side Effects of Fluconazole
Fluconazole may cause some unpredictable side effects, including baldness and dizziness.
Fluconazole interacts with hundreds of drugs and can often increase the levels of many drugs in the blood, which may cause dangerous interactions.
It's always important to share with your doctor and pharmacist all of the medications you are taking.
This includes not only prescriptions medications but also products that may not seem like medication, such as over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), and herbals along with any illegal and recreational drugs.
You should not take fluconazole if you are taking the following drugs:
- Hismanal (astemizole)
- Norpace (disopyramide)
- Erythromycin-containing drugs, including drugs containing erythromycin base, erythyromycin ethylsuccinate, erythromycin lactobionate, or eryrthromyvin stearate
- Medications for irregular heartbeat like Covert (ibutilide), Norpace (disopyramide), Promestyl, Procan, or Procanbid (procainamide)
- Lozol (indapamide)
- Juxtapid (lomitapide)
- Nebupent (pentamidine)
- Orap (pimozide)
You should talk to your doctor about drug options other than fluconazole if you're taking any of the following:
Fluconazole and Alcohol
You should avoid or limit drinking alcohol while taking fluconazole.
Since both can cause headaches and stomach discomfort, drinking alcohol while taking fluconazole may worsen these side effects.
Fluconazole and Grapefruit Juice
The liver breaks down fluconazole and grapefruit juice the same way.
Grapefruit juice slows down how quickly the body is able to break down the fluconazole, which could cause fluconazole levels in the blood to rise dangerously high.
You should therefore avoid eating grapefruit and drinking grapefruit juice while taking fluconazole.
Fluconazole is available in pill, liquid, and cream form.
You should always take the exact amount each day that your doctor prescribed, and be sure to finish the entire amount of the medication -- even if you no longer experience symptoms -- unless your doctor has instructed otherwise.
To treat fungus in the mouth, known as thrush, your doctor may have you take 200 milligrams (mg) the first day and then 100 mg per day for at least two weeks.
People with fungal infections of the esophagus may take 200 mg on the first day and then 100 mg per day for at least three weeks.
After the fungus goes away, you should continue taking fluconazole for at least two weeks. Depending on how well the medication works for you, your doctor may increase your daily dose up to 400 mg per day.
To treat yeast infections of the vagina, only a one-time dose of 150 mg by mouth is needed.
To help try to avoid or prevent fungal infections while treating bone marrow transplant patients, the usual dose is 400 mg per day.
People with a type of meningitis (commonly seen in those with AIDS) are typically prescribed 400 mg or more of fluconazole for the first day and then 200 mg per day.
Depending on how your body responds to the medication, your doctor may have you take doses as high as 800 mg per day.
Your doctor may also have you continue taking fluconazole until the test results on your brain fluid (cerebral spinal fluid) come back negative.
Fluconazole dosing is usually based on the weight of the child, so ask your healthcare provider for more information.
If you suspect an overdose, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Missed Dose of Fluconazole
If you miss a dose of Fluconazole, try to take it as soon as you remember.
However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule.
Don't double up on doses to make up for a missed one.
By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-02-26
Copyright © 2014 Everyday Health Media, LLC
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Video: How Long Does It Take Fluconazole To Work?
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